Hematopoietic and mesenchymal stem cells: polymeric nanoparticle uptake and lineage differentiation

• Ivonne Brüstle,
• Thomas Simmet,
• Gerd Ulrich Nienhaus,
• Katharina Landfester and
• Volker Mailänder

Beilstein J. Nanotechnol. 2015, 6, 383–395, doi:10.3762/bjnano.6.38

• analyzed with lineage specific cluster of differentiation markers. On the other hand qPCR analysis showed significant changes in the expression of some (but not all) investigated lineage markers for both primary cell types. Keywords: cytokine secretion; differentiation; hematopoietic stem cells

• toxicity (Supporting Information File 1, Figure S3). Cytokine secretion of hMSCs and hHSCs To determine if the polymeric nanoparticles have an impact on the cell functionality, IL-6 und IL-8 were chosen as they have been reported to be secreted by hMSCs [21][22]. The concentration of these two cytokines

• IL-8 secretion (Figure 3). The lone PLLA particles also showed no influence on the cytokine secretion. In contrast, the PLLA–Fe particles dramatically increased the IL-8 release while the IL-6 secretion was not altered (Figure 4). For hHSCs, cell functionality was tested by quantitative analysis of

Friction and durability of virgin and damaged skin with and without skin cream treatment using atomic force microscopy

• Bharat Bhushan,
• Si Chen and
• Shirong Ge

Beilstein J. Nanotechnol. 2012, 3, 731–746, doi:10.3762/bjnano.3.83

• degranulation, cytokine secretion, increased skin roughness and physical discomfort [6][10][11]. Skin care products are developed to moisturize skin surface by humectants, which are a component of skin creams that can increase the moisture retention of stratum corneum and reduce the incidence of dry and flaky